June 27th | Neurotransmitters, Drugs and Brain Function Wiley (2001)
Mast cells and the release of 5-HT, may also release histamine which causes vasodilation, swelling and itching and ATP and adenosine are also involved in inflammatory conditions. Substance P and CGRP released from peripheral endings of primary afferents? Ia axon reflex) can also cause mast cells degranulate and release 5-HT. The peptides cause a number of effects, including vasodilation, plasma extravasation and mast cell degranulation and ATP can lead to a direct activation of nociceptors via activation of P2X receptors. Other factors such as nerve growth factor? GF) and cytokines are also important at the periphery and the resulting changes in the phenotype of sensory neurons have been shown as one of the resulting effects. Thus, NGF is upregulated in the area of ??tissue injury and then binds to its receptor highaffinity, the trkA receptor, the family of tyrosine kinase. NGF receptor and are then internalized and transported to the cell body in the dorsal root ganglion. Here, there is a resulting change in gene expression so that the gene prepro tachykinins is activated. And tissue injury causes complex changes in the transduction of painful stimuli. Figure 21.1 shows some of the mediators at the periphery with their receptors.
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Tags: And, Causes, Changes, complex, Damage, headache, migraine, vascular
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